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Kirkwood Land

Kirkwood LandKirkwood M. Land
Department of Biological Sciences
University of the Pacific
Stockton, CA 95211  

RESEARCH INTERESTS
We use interdisciplinary approaches to explore human and veterinary anti-protozoal drug discovery and development. In collaboration with other Universities and pharmaceutical companies, we are identifying lead compounds and potential new therapeutics for drug resistant parasite and bacterial infections.    We are also interested in the molecular characterization and epidemiology of emerging pathogens of humans, domesticated animals, and wildlife using a One Health approach.    

CURRENT EXTERNAL RESEARCH FUNDING

(1) Winn Feline Research Foundation (2013-2015)
Co-Principal Investigator "Utilization of an in vitro luciferase assay to determine efficacy of novel 5-nitroimidazole derivatives and proton pump inhibitors against ronidazole-resistant and susceptible feline Tritrichomonas foetus isolateswith Stanley L. Marks, BVSc, PhD, Dip ACVIM, Dip ACVN, University of California, Davis, School of Veterinary Medicine

(2) United States Equesterian Federation (2014-2016)
Co-Principal Investigator "High Throughput Drug Discovery against Equine Protozoal Myeloencephalitis" with Heather M. Fritz, DVM, PhD and Patricia A. Conrad, DVM, PhD, University of California, Davis, School of Veterinary Medicine. 

(3) Center for Equine Health, School of Veterinary Medicine, University of California, Davis (2013)
Co-Principal Investigator "High Throughput Drug Discovery against Equine Protozoal Myeloencephalitis" with Heather M. Fritz, DVM, PhD and Patricia A. Conrad, DVM, PhD, University of California, Davis, School of Veterinary Medicine. 

PEER-REVIEWED PUBLICATIONS (2007 to present)
*indicates University of the Pacific student co-authors

Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, LAND KM, Beauchene J*, Schreiber K*, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC.  (2007) Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.  Antimicrobial Agents and Chemotherapy 51(6): 2164-72M.

Sajid, M. J. Blackman, P. Doyle, C. He, LAND KM, C. Lobo, Z. Mackey, M. Ndao, S. L. Reed, B. Shiels, R. Swenerton, and W. Weir. (2009) Proteases of Parasitic Protozoa.  In Selzer (Ed.): Drug Discovery in Infectious Diseases: From Molecular Targets to Drug Candidates. PP.177-201.

*Dornbush, PJ, *Cho CH, *Chang E, *Lu Xu, Russu, WA, Wrischnik LA, and LAND, KM Preliminary Studies of 3,4-Dichloroaniline Amides as Antiparasitic Agents: Structure Activity Analysis of a Compound Library in vitro Against Trichomonas vaginalis. Bioorganic and Medicinal Chemistry Letters 2010; 20(17): 5299-301

*Dornbush, PJ, *Vazquez-Anaya G, *Shokar A, *Nguyen S, Wnuk SF, Wrischnik LA, LAND,KM  AldoHyc Hydrolase of Trichomonas vaginalis: Studies of the effects of 5'-deoxy-5'-(iodomethylene) adenosine and related 6-N-cyclopropyladenosine analogues on in vitro culture. Bioorganic and Medicinal Chemistry Letters 2010; 20(24): 7466-8

LAND, KM and Cheng, L.W. (2010) The botulinum neurotoxin: a deadly protease with applications to human medicine.  In A. Mendez-Vilas (Ed.) Current Research and Technology in Applied Microbiology and Microbial Biotechnology Vol. 2: pp.  683-690.

Chellan, P., Stringer, T., *Shokar, A, *Dornbush, PJ, *Vazquez-Ayana, G., LAND KM, Chibale, K., and Smith GS. Synthesis and in vitro Evaluation of Palladium (II) Salicylaldiminato Thiosemicarbazone Complexes Against Trichomonas vaginalis. Journal of Inorganic Biochemistry 2011; 105:1562-1568.

Cheng LW, LAND, KM, L. H. Stanker  (2012) Current methods for detecting the presence of botulinum neurotoxins in food and other biological samples.  In Bioterrorism pp.1-16 (In Tech publishers). 

*Shokar, A., *Au, A., *An, S.H., Zayas, J., Wnuk, S.F., LAND, KM. (2012) Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β, D-arabinofuranosyl) adenine. Bioorganic and Medicinal Chemistry Letters 22:4203-4205.

Chellan, P., LAND KM,  *Shokar, A, *Au, A, *An, SH, CM Clavel, PJ Dyson, C de Kock, PJ Smith, J Mao, K Chibale, GS. Smith. (2012) Exploring the Versatility of Cycloplatinated Thiosemicarbazones in Biology and Catalysis.  Organometallics 31 (16); 5791-5799

Adams, M., Li, Y.,  Khot, H., De Kock, C., Smith, P.J., LAND K, Chibale, K., and Smith, G.S. (2013) The Synthesis and Antiparasitic Activity of Aryl- and Ferrocenyl-Derived Thiosemicarbazone Ruthenium(II)-Arene Complexes.  Dalton Transactions 42(13): 4677-85

LAND KM, Wrischnik, LA (2013) Basic biology of Trichomonas vaginalis: current explorations and future directions.  Sexually Transmitted Infections 89(6): 416-417.

Raj, R, Singh, P., *Haberkern, NT,  *Faucher, RM,  *Patel, N., LAND, KM, Kumar, V. (2013) Synthesis of 1H-1,2,3-triazole linked β-lactam-Isatin Bifunctional Hybrids and preliminary analysis of in vitro activity against the protozoal parasite Trichomonas vaginalisEuropean Journal of Medicinal Chemistry 4:1018-1024.

Nisha, N., Mehra, V., *Hopper, M., *Patel, N., *Hall, D., Wrischnik, LA,  LAND, KM,  Kumar, V. (2013) Design and synthesis of -amino alcohol based -lactam-isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis.  Medicinal Chemistry Communications 4:1018-1024.

Stringer, T., Taylor, D., de Kock, C.,  Guzgay, H.,  *Au, A., *An, SH, *Sanchez, B., * O'Connor, R., *Patel, N.,  LAND, KM,  Smith, PJ,  Hendricks, DT,  Egan, TG,  Smith, GS. (2013) Synthesis, characterization, antiparasitic and cytotoxic evaluation of thioureas conjugated to polyamine scaffolds.  European Journal of Medicinal Chemistry 69:90-8.

Ndao, M., Nath-Chowdhury, M., Sajid, M., Marcus, V., S. T. Mashiyama, J. Sakanari, E. Chow, Z. Mackey, LAND, KM,  M. P. Jacobson, C. Kalyanaraman, J. H. McKerrow, M. J. Arrowood, C. R. Caffrey.  (2013) A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrobial Agents and Chemotherapy 57(12):6063-73

Chellan, P, LAND, KM, *A. Shokar, *A. Au, *S. H. An, D. Taylor, P. J. Smith, K. Chibale, G. S. Smith (2013) Di- and Trinuclear Ruthenium‑, Rhodium‑, and Iridium- Functionalized Pyridyl Aromatic Ethers: A New Class of Antiparasitic Agents. Organometallics (in press)

Chellan, P, LAND, KM, *A. Shokar, *A. Au, *S. H. An, D. Taylor, P. J. Smith, K. Chibale, G. S. Smith (2014) Synthesis and study of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents. Dalton Transactions  43(2):513-26

Martichonok, VV, Chiang, PK, *Dornbush, PJ,  LAND, KM.  (2014) On Regioselectivity of Aldol Condensation of Aromatic Aldehydes with Borate Complex of Acetylacetone. Synthetic Communications 44:1245-1250.

Raj, R, Singh, P., *Chang, K, LAND, KM, Kumar, V. (2014)  N-propargylated isatin-mannich mono- and bis- adducts: Synthesis and preliminary analysis of in vitro activity against the protozoal pathogen Tritrichomonas foetusEuropean Journal of Medicinal Chemistry 74:657-63.

Raghu R, Sharma, V., Hopper, M., Patel, N., Hall, D., Wrischnik, L.A., LAND, K.M., Kumar, V. (2014) Synthesis and preliminary in vitro activity of mono- and bis-1H-1,2,3-triazole-tethered β-lactam-isatin conjugates against the human protozoal pathogen Trichomonas vaginalis.  Medicinal Chemistry Research. 23:3671-3680

Nisha, N., Tran, R., Yang, D., Hall, D., Hopper, M., Wrischnik, LA, LAND, KM, Kumar, V.  Cu(I)Cl-promoted synthesis of novel N-alkylated isatin analogs with an extension toward isatin-4-aminoquinoline conjugates: in vitro analysis against Trichomonas vaginalisMedicinal Chemistry Research. DOI 10.1007/s00044-014-1024-y

Girard, YA, Rogers, KA, Gerhold, R., LAND, KM, Lenaghan, SC, Woods, L., *Haberkern, N., *Hopper, M., Cann, JD, Johnson, CK. (2014) Characterization of Trichomonas stableri n. sp., a novel etiologic agent associated with avian trichomonosis.  International Journal for Parasitology: Parasites and Wildlife. 3(1):32-40.

Maritz JM, LAND KM, Carlton JM, Hirt RP. (2014) What is the importance of zoonotic trichomonads for human health?  Trends in Parasitology 30(7): 333-341Featured on the cover of July 2014 issue.   

Kirkwood Land, Ph.D.
Associate Professor, Biological Sciences
Email Link Email - Phone: 209.946.7609
Office: Biology Room 249
 Curriculum Vitae

Area:  Biology of the human parasite Trichomonas vaginalis