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Kirkwood Land

Kirkwood LandKirkwood M. Land
Department of Biological Sciences
University of the Pacific
Stockton, CA 95211  

RESEARCH FOCUS

Interdisciplinary studies of human and veterinary anti-protozoal drug discovery and development.  

CURRENT FUNDING

Winn Feline Research Foundation

Co-Principal Investigator "Utilization of an in vitro luciferase assay to determine efficacy of novel 5-nitroimidazole derivatives and proton pump inhibitors against ronidazole-resistant and susceptible feline Tritrichomonas foetus isolates with Stanley L. Marks, BVSc, PhD, Dip ACVIM, Dip ACVN, University of California, Davis, School of Veterinary Medicine

PEER-REVIEWED PUBLICATIONS (2007 to present)* indicates Pacific student co-authors

Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, LAND, K.M., Beauchene J*, Schreiber K*, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC.  (2007) Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.  Antimicrobial Agents and Chemotherapy 51(6):2164-72

M. Sajid, M. J. Blackman, P. Doyle, C. He, LAND KM, C. Lobo, Z. Mackey, M. Ndao, S. L. Reed, B. Shiels, R. Swenerton, and W. Weir. (2009) Proteases of Parasitic Protozoa.  In Selzer (Ed.): Drug Discovery in Infectious Diseases: From Molecular Targets to Drug Candidates. PP.177-201.

*Dornbush, PJ, *Cho CH, *Chang E, *Lu Xu, Russu, WA, Wrischnik LA, and LAND, KM Preliminary Studies of 3,4-Dichloroaniline Amides as Antiparasitic Agents: Structure Activity Analysis of a Compound Library in vitro Against Trichomonas vaginalis.   Bioorganic and Medicinal Chemistry Letters 2010; 20(17):5299-301

*Dornbush, PJ, *Vazquez-Anaya G, *Shokar A, *Nguyen S, Wnuk SF, Wrischnik LA, LAND, KM  AldoHyc Hydrolase of Trichomonas vaginalis: Studies of the effects of 5'-deoxy-5'-(iodomethylene) adenosine and related 6-N-cyclopropyladenosine analogues on in vitro culture. Bioorganic and Medicinal Chemistry Letters 2010; 20(24):7466-8

LAND, KM and Cheng, L.W. (2010) The botulinum neurotoxin: a deadly protease with applications to human medicine.  In A. Mendez-Vilas (Ed.) Current Research and Technology in Applied Microbiology and Microbial Biotechnology Vol. 2: pp.  683-690.

Chellan, P., Stringer, T., *Shokar, A, *Dornbush, PJ, *Vazquez-Ayana, G., LAND KM, Chibale, K., and Smith GS. Synthesis and in vitro Evaluation of Palladium(II) Salicylaldiminato Thiosemicarbazone Complexes Against Trichomonas vaginalis. Journal of Inorganic Biochemistry 2011; 105:1562-1568.

Cheng LW, LAND, KM, L. H. Stanker  (2012) Current methods for detecting the presence of botulinum neurotoxins in food and other biological samples.  In Bioterrorism pp.1-16 (In Tech publishers). 

*Shokar, A., *Au, A., *An, S.H., Zayas, J., Wnuk, S.F., LAND, KM. (2012) Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine. Bioorganic and Medicinal Chemistry Letters 22:4203-4205.

Chellan, P., LAND KM,  *Shokar, A, *Au, A, *An, SH, CM Clavel, PJ Dyson, C de Kock, PJ Smith, J Mao, K Chibale, GS. Smith. (2012) Exploring the Versatility of Cycloplatinated Thiosemicarbazones in Biology and Catalysis.  Special Issue of Organometallics 31 (16); 5791-5799

Adams, M., Li,Y.  Khot, H., De Kock, C., Smith, P.J., LAND K, Chibale, K., and Smith, G.S. (2013) The Synthesis and Antiparasitic Activity of Aryl- and Ferrocenyl-Derived Thiosemicarbazone Ruthenium(II)-Arene Complexes.  Dalton Transactions (29 Jan 2013, Epub ahead of print)

LAND KMWrischnik, LA (2013) Basic Biology of Trichomonas vaginalis: current explorations and future directions.   Sexually Transmitted Infections (in press)

Raj, R, Singh, P., *Haberkern, NT,  *Faucher, RM,  *Patel, N.,  LAND, KM,  Kumar, V. (2013)  Synthesis of 1H-1,2,3-triazole linked β-lactam-Isatin Bifunctional Hybrids and preliminary analysis of in vitro activity against the protozoal parasite Trichomonas vaginalis.  In press, European Journal of Medicinal Chemistry.

Nisha, N., Mehra, V., *Hopper, M., *Patel, N., LAND, KM,  Kumar, V. Design, synthesis of b-amino alcohol based b-lactam-isatin chimeras and preliminary analysis of in vitro activity against T. vaginalis (In press,  Medicinal Chemistry Communications).

Stringer, T., Taylor, D., de Kock, C.,  Guzgay, H.,  *Au, A., *An, SH, *Sanchez, B., * O'Connor, R., *Patel, N.,  LAND, KM,  Smith, PJ,  Hendricks, DT,  Egan, TG,  Smith, GS.  Synthesis, characterization, antiparasitic and cytotoxic evaluation of thioureas conjugated to polyamine scaffolds.  In press,  Eur J Med Chem.

Ndao, M., Nath-Chowdhury, M., Sajid, M., Marcus, V., S. T. Mashiyama, J. Sakanari, E. Chow, Z. Mackey, LAND, KM,  M. P. Jacobson, C. Kalyanaraman, J. H. McKerrow, M. J. Arrowood, C. R. Caffrey.   A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection.  In press,  Antimicrobial Agents and Chemotherapy. 

Kirkwood Land, Ph.D.

Associate Professor, Biological Sciences
Email Link Email - Phone: 209.946.7609
Office: Biology Room 249
 Curriculum Vitae

Area:  Biology of the human parasite Trichomonas vaginalis