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Thomas J. Long School of Pharmacy and Health Sciences Admissions
Office of the Dean
751 Brookside Road
Stockton, CA 95207
Mailing - 3601 Pacific Avenue Stockton, CA 95211

Mamoun Alhamadsheh, B.Pharm., Ph.D.

Assistant Professor
Department of Pharmaceutics and Medicinal Chemistry

Phone: (209) 946-3164
E-mail: malhamadsheh@pacific.edu

At Pacific Since:

Ph.D., 2004, University of Toledo, Toledo, OH
B.Pharm., 1999, Jordan University of Science and Technology, Jordan

Postdoctoral Training:
Stanford University, 2008-2011
Portland State University, 2004-2007

Research Interests
• Protein-protein interactions
• Amyloid beta aggregation in Alzheimer's disease
• Transthyretin Amyloidosis

Research Summary
Our laboratory employs an interdisciplinary approach to study protein-protein interactions (PPIs), combining synthetic organic chemistry with biochemistry and molecular biology. We are interested in developing small molecules that can be used to probe or inhibit PPIs. These small molecules would be used to understand the structure and function of multi-protein complexes as well as to develop new leads for drug discovery. Due to the urgent need for new drugs, we are particularly interested in developing chemical tools and therapeutic agents for protein aggregation (a type of PPIs) diseases such as Alzheimer's disease and Transthyretin Amyloidosis.

Mamoun Alhamadsheh
had his article "Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity" published and featured on the cover in Science Translational Medicine magazine. It was also mentioned in Chemical & Engineering News, published by the American Chemical Society, and The Alzheimer Research Forum.