Mamoun Alhamadsheh, B.Pharm., Ph.D.
Assistant Professor 
Department of Pharmaceutics and Medicinal Chemistry
Phone: (209) 946-3164
E-mail: malhamadsheh@pacific.edu
At Pacific Since:
2011
Education:
PhD., 2004, University of Toledo, Toledo, OH
B.Pharm., 1999, Jordan University of Science and Technology, Jordan
Postdoctoral Training:
Stanford University, 2008-2011
Portland State University, 2004-2007
Research Interests
• Protein-protein interactions
• Amyloid beta aggregation in Alzheimer's disease
• Transthyretin Amyloidosis
Research Summary
Our laboratory employs an interdisciplinary approach to study protein-protein interactions (PPIs), combining synthetic organic chemistry with biochemistry and molecular biology. We are interested in developing small molecules that can be used to probe or inhibit PPIs. These small molecules would be used to understand the structure and function of multi-protein complexes as well as to develop new leads for drug discovery. Due to the urgent need for new drugs, we are particularly interested in developing chemical tools and therapeutic agents for protein aggregation (a type of PPIs) diseases such as Alzheimer's disease and Transthyretin Amyloidosis.
Publications
Mamoun Alhamadsheh had his article "Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity" published and featured on the cover in Science Translational Medicine magazine. It was also mentioned in Chemical & Engineering News, published by the American Chemical Society, and The Alzheimer Research Forum.