William K. Chan, Pharm.D., Ph.D.
Department of Pharmaceutics and Medicinal Chemistry
• Aryl hydrocarbon receptor and Arnt-dependent pathways
• Rational drug design
• Cytochrome P450 mediated drug interactions
• Recombinant Protein Expression
Dr. Chan graduated from University of California, San Francisco in 1986 with a doctor of pharmacy and a doctor of philosophy in 1991. He then received post-doctoral training at University of California, Davis in 1992 for one year in environmental toxicology. He followed this with another post-doctoral fellowship at Northwestern University Medical School for four years in molecular pharmacology. In 1996, Dr. Chan joined the faculty at University of the Pacific as Assistant Professor. In the future, he hopes to continue gaining funding for his lab to make new discoveries that benefit the community as well as having more opportunities for collaboration with his fellow faculty members on and off campus.
Dr. Chan enjoys University of the Pacific for its beautiful campus and good working environment. He also enjoys teaching, Pacific's student-centered learning environment, and Pacific's support of faculty research. In his spare time, Dr. Chan enjoys playing racquetball.
Wang, Y., Yang, D., Chang, A., Zhao, B., Denison, M., Chan, W. K. and Xue, L. (2011) Synthesis of a ligand-quencher conjugate for the ligand binding study of the aryl hydrocarbon receptor using a FRET assay, Med. Chem. Res. Feb 4, doi:10.1007/s00044-011-9575-7.
Park, M. S., Chu, F., Xie, J., Wang, Y., Bhattacharya, P. and Chan, W. K. (2011) Identification of cyclophilin-40 interacting proteins reveals potential cellular function of cyclophilin-40, Anal. Biochem. 410, 257-265.
Krueger. A., Parker, A., Ren, J., Chan, W. K. and Russell, S. C. (2011) Characterization of disulfide bridges in E. coli expressed AhRC∆553 via SDS-PAGE & AP-MALDI-MS. CSUPERB Abstract, Jan.
Nguyen, P. M., Wang, D., Li, Y. and Chan, W. K. (2011) p23 co-chaperone is essential for the optimal function of the aryl hydrocarbon receptor in Hepa1c1c7 cells by modulating the AhR content. FASEB Abstract, Washington D. C., April.
Wang, Y., Li, Y., Wang, D. and Chan, W. K. (2011) The aryl hydrocarbon receptor nuclear translocator-interacting peptide 1 suppresses hypoxia inducible factor-1 alpha signaling via an Arnt-dependent mechanism. FASEB Abstract, Washington D. C., April.