University of the PACIFIC

Xin Guo, Ph.D.

Associate Professor
Department of Pharmaceutics and Medicinal Chemistry

Phone: 209.946.2321
Email: xguo@pacific.edu

Research Interests

• Drug delivery and drug targeting using liposomes and other nanoparticulates;

• Delivery of biomacromolecules including DNA, siRNA and proteins using liposomes

Biography

Dr. Xin Guo graduated from Fudan University, formerly known as Shanghai Medical University, School of Pharmacy with a bachelor of science and from Duquesne University School of Pharmacy with a master of science, both in medicinal chemistry. He earned his doctor of philosophy from University of California San Francisco in pharmaceutical chemistry. Dr. Guo has been at University of Pacific since 2003.

On his spare time, he enjoys singing and playing chess.

Publications

Liu, X.; Zheng, Y.; Samoshina, N.M.; Franz, A.H.; Guo, X.; Samoshin, V.V. Fliposomes: pH-triggered conformational flip of new trans-2-aminocyclohexanol-based amphiphiles causes instant cargo release in liposomes. J Liposome Res. 2012 Jul 9. [Epub ahead of print]

Chen, H.; Zhang, H.; Thor, D.; Rahimian, R.; Guo, X. Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery. Eur J Med Chem 2012, 52:159-72.

Zheng, Y.; Liu, X.; Samoshina, N. M.; Chertkovc, V.A.; Franza, A. H.; Guo, X.; Samoshin, V.V. Fliposomes: pH-controlled release from liposomes containing new trans-2-morpholinocyclohexanol-based amphiphiles that perform a conformational flip and trigger an instant cargo release upon acidification. Nat Product Comm. 2011. 6, 1-3.

Samoshina, N.M.; Liu, X.; Brazdova, B.; Franz, A. H.; Samoshin, V.V.; Xin Guo, X. Fliposomes: pH-Sensitive liposomes containing a trans-2-morpholinocyclohexanol-based lipid that performs a conformational flip and triggers an instant cargo release in acidic medium. Pharmaceutics 2011, 3(3), 379-405.

Brazdova, B; Zhang, N; Samoshin V. V.; Guo, X. trans-2-Aminocyclohexanol as a pH-sensitive conformational switch in lipid amphiphiles. Chem Comm. 2008. DOI:10.1039/B807704E.

Chen, H.; Zhang, H.; McCallum, C.M.; Szoka, F. C.; Guo, X. Unsaturated cationic ortho esters for endosome permeation in gene delivery. J Med Chem. 2007, 50, 4269-78.