Robert F. Halliwell, PhD
Department of Physiology and Pharmacology
Our lab is addressing the properties and potential value of neurons derived from a variety of human stem cells for studies in neuropharmacology and neurotoxicology; I have also published work in the history of medicine.
Primary Researchers Associated With Our Laboratory
Robert F. Halliwell, PhD (Principal Investigator)
Leanne Coyne, PhD (Associate Professor)
William S. Cao, PhD (Post-Doctoral Researcher)
Kathleen L. Metz, BS (Graduate Student)
Dr. Robert F. Halliwell received his bachelor of science from the University of Stirling in Scotland in 1983, his master of science from University College London in 1985, and his doctor of philosophy from the University of Dundee in Scotland in 1992. He received a Fulbright Fellowship to complete a three-year postdoctoral training at the University of California, Irvine. Dr. Halliwell is a Professor of Neuroscience & Clinical Pharmacology at the School; he previously held a lectureship in Neuroscience at the University of Durham, England and a Research Fellowship at the University of California, Irvine.
Cao WS, Livesey JC & Halliwell RF. An evaluation of a human stem cell line to identify risk of developmental neurotoxicity with antiepileptic drugs. Toxicol In Vitro, 29 (3): 592-599 (2015).
Coyne L, Shan M, Przyborski SA, Hirakawa R & Halliwell RF. Neuropharmacological properties of neurons derived from human stem cells, Neurochemistry International, 59(3): 404-12 (2011).
Halliwell RF Letter from America: The Potential of Stem Cells, British Neuroscience Ass Bulletin, 61: 11 (2010).
C-R Pruell, A-H Maehle & RF Halliwell (Book). A Short History of the Drug Receptor Concept, Palgrave Macmillan (2009). ISBN-13: 9780230554153.
Khansari PS & Halliwell RF, Evidence for Neuroprotection by the Fenamate NSAID, Mefenamic Acid. Neurochemistry International, 55: 683-688 (2009).
Harris D, et al., Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the α5 subunit. Journal of Medicinal Chemistry, 51: 3788-3803 (2008).
Halliwell, RF. A Short history on the rise of the molecular pharmacology of ionotropic drug receptors, Trends in Pharmacological Sciences, 28 (5): 214 - 219 (2007).
Coyne L, et al., Characterization of the interaction between fenamate NSAIDs and hippocampal neuron GABAA receptors. Neurochemistry International, 51: 440 - 446 (2007).
Johnstone TBC, et al., Antibacterial quinolones yield novel anxiolytics. Nature Medicine, 10 (1): 31-32 (2004).
Maehle, AH, Prüll, CR & Halliwell, RF. The emergence of the drug receptor theory. Nature Reviews, Drug Discovery, 1: 637-641 (2002).