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The Cheminar

Tuesday, December 06, 2022
11:00 a.m. - 12:00 p.m.

Add to Calendar 2022-12-06 11:00:00 2022-12-06 12:00:00 The Cheminar The Cheminar: Visualizing T Cell Signaling at the Single Molecule Level Tuesday, Dec. 6, 2022 — 11 a.m. to Noon — Classroom Bldg. 170 Zach Katz Research Biology Dept Genentech T cells rely on the precise recognition of presented antigenic peptides among a sea of other signaling molecules and extracellular stimuli. A series of critical gates and proofreading mechanisms keep aberrant stimulation at bay until a threshold is overcome and the rapid condensation of signaling molecules drive downstream activation events. Live cell single molecule microscopy allows us to visualize these signaling molecules and precisely track how they organize and change depending on signal strength or after mutation of key sites of motif interactions. Our aim is to understand how costimulatory molecules, being the key targets of many immunotherapies, contribute to local biomolecular condensation dynamics during T cell activation. We highly recommend you attend it in person. But if you cannot, here is the Zoom link to join online: https://pacific.zoom.us/j/93581261718 Zoom Meeting ID: 935 8126 1718 One tap mobile+16699009128,,93581261718# US (San Jose)+12532158782,,93581261718# US (Tacoma) Dial by your location +1 669 900 9128 US (San Jose) +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) +1 301 715 8592 US (Germantown) +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) Meeting ID: 935 8126 1718 Find your local number: https://pacific.zoom.us/u/axmW6NT09 3601 Pacific Ave, Stockton, CA 95211, USA College of the Pacific College of the Pacific America/Los_Angeles public

The Cheminar: Visualizing T Cell Signaling at the Single Molecule Level

Tuesday, Dec. 6, 2022 — 11 a.m. to Noon — Classroom Bldg. 170

Zach Katz
Research Biology Dept
Genentech

T cells rely on the precise recognition of presented antigenic peptides among a sea of other signaling molecules and extracellular stimuli. A series of critical gates and proofreading mechanisms keep aberrant stimulation at bay until a threshold is overcome and the rapid condensation of signaling molecules drive downstream activation events. Live cell single molecule microscopy allows us to visualize these signaling molecules and precisely track how they organize and change depending on signal strength or after mutation of key sites of motif interactions. Our aim is to understand how costimulatory molecules, being the key targets of many immunotherapies, contribute to local biomolecular condensation dynamics during T cell activation.

We highly recommend you attend it in person. But if you cannot, here is the Zoom link to join online:

https://pacific.zoom.us/j/93581261718
Zoom Meeting ID: 935 8126 1718

One tap mobile

+16699009128,,93581261718# US (San Jose)

+12532158782,,93581261718# US (Tacoma)

Dial by your location

+1 669 900 9128 US (San Jose)

+1 253 215 8782 US (Tacoma)

+1 346 248 7799 US (Houston)

+1 301 715 8592 US (Germantown)

+1 312 626 6799 US (Chicago)

+1 646 558 8656 US (New York)