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The Cheminar

Tuesday, November 15, 2022
11:00 a.m.

Add to Calendar 2022-11-15 11:00:00 2024-12-11 02:54:22 The Cheminar The Cheminar Nov. 15th, 2022 — 11 a.m. - Noon — Classroom Bldg. 170 Light Paves New Roads for Therapeutics and Chemical Tools Jeremy Kodanko Dept of Chemistry Wayne State University Light allows for precise spatiotemporal control over compound activation and the release of biologically active compounds. This seminar will discuss recent developments in applying Ru(II)-based photocaging towards biological problems. Our group designed and synthesized Ru(II)-based platforms for the photoinduced delivery of cysteine protease and cytochrome P450 inhibitors to achieve selective control over enzyme inhibition in living cells, inhibition of in situ metabolism and creating drug synergy. We describe the design, synthesis and biological evaluation of Ru(II) photosensitizers with dual reactivity, where light triggers photorelease and photosensitization. These novel photosensitizers were conjugated to irreversible inhibitors of the cysteine protease cathepsin B, to develop new combination therapeutics for targeting invasive cancers and inhibitors of cytochrome P450 enzymes, to work synergistically with current chemotherapeutic drugs. Luminescent metal-based inhibitors will be described that are capable of monitoring active site occupancy of the cytochrome P450 enzyme CYP3A4. 3601 Pacific Ave, Stockton, CA 95211, USA College of the Pacific College of the Pacific America/Los_Angeles public

The Cheminar

Nov. 15th, 2022 — 11 a.m. - Noon — Classroom Bldg. 170

Light Paves New Roads for Therapeutics and Chemical Tools

Jeremy Kodanko
Dept of Chemistry
Wayne State University

Light allows for precise spatiotemporal control over compound activation and the release of biologically active compounds. This seminar will discuss recent developments in applying Ru(II)-based photocaging towards biological problems. Our group designed and synthesized Ru(II)-based platforms for the photoinduced delivery of cysteine protease and cytochrome P450 inhibitors to achieve selective control over enzyme inhibition in living cells, inhibition of in situ metabolism and creating drug synergy. We describe the design, synthesis and biological evaluation of Ru(II) photosensitizers with dual reactivity, where light triggers photorelease and photosensitization. These novel photosensitizers were conjugated to irreversible inhibitors of the cysteine protease cathepsin B, to develop new combination therapeutics for targeting invasive cancers and inhibitors of cytochrome P450 enzymes, to work synergistically with current chemotherapeutic drugs. Luminescent metal-based inhibitors will be described that are capable of monitoring active site occupancy of the cytochrome P450 enzyme CYP3A4.